diff --git a/setup.py b/setup.py
index 9d529a36..db9595f7 100644
--- a/setup.py
+++ b/setup.py
@@ -60,7 +60,7 @@ setup(
     license = 'New BSD',
     url = 'https://github.com/mitogen-hq/mitogen/',
     packages = find_packages(exclude=['tests', 'examples']),
-    python_requires='>=2.4, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*, !=3.5.*, <4',
+    python_requires='>=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*, !=3.5.*',
     zip_safe = False,
     classifiers = [
         'Environment :: Console',
@@ -70,10 +70,6 @@ setup(
         'Operating System :: MacOS :: MacOS X',
         'Operating System :: POSIX',
         'Programming Language :: Python',
-        'Programming Language :: Python :: 2',
-        'Programming Language :: Python :: 2.4',
-        'Programming Language :: Python :: 2.5',
-        'Programming Language :: Python :: 2.6',
         'Programming Language :: Python :: 2.7',
         'Programming Language :: Python :: 3',
         'Programming Language :: Python :: 3.6',