diff --git a/changelogs/fragments/85542-warning-when-using-seuser-on-alpine.yml b/changelogs/fragments/85542-warning-when-using-seuser-on-alpine.yml
new file mode 100644
index 00000000000..b32ff161936
--- /dev/null
+++ b/changelogs/fragments/85542-warning-when-using-seuser-on-alpine.yml
@@ -0,0 +1,2 @@
+bugfixes:
+  - user - The seuser parameter will be ignored on Alpine and print a warning (https://github.com/ansible/ansible/issues/85542).
\ No newline at end of file
diff --git a/lib/ansible/modules/user.py b/lib/ansible/modules/user.py
index b81258153fd..24b04b28412 100644
--- a/lib/ansible/modules/user.py
+++ b/lib/ansible/modules/user.py
@@ -44,6 +44,7 @@ options:
     seuser:
         description:
             - Optionally sets the C(seuser) type C(user_u) on SELinux enabled systems.
+            - This parameter will be ignored on macOS, *BSD, BusyBox-based distros and Buildroot.
         type: str
         version_added: "2.1"
     group:
@@ -1345,6 +1346,12 @@ class User(object):
             return None
         return ssh_public_key
 
+    def check_seuser_support(self):
+        # Now only Generic platform supports the seuser parameter
+        if self.platform != 'Generic':
+            self.module.warn(f"The 'seuser' parameter is not supported on {self.distribution or self.platform} "
+                             "as it lacks SELinux support and has been ignored.")
+
     def create_user(self):
         # by default we use the create_user_useradd method
         return self.create_user_useradd()
@@ -3355,6 +3362,9 @@ def main():
                 if not os.path.isdir(parent):
                     path_needs_parents = True
 
+            if user.seuser:
+                user.check_seuser_support()
+
             (rc, out, err) = user.create_user()
 
             # If the home path had parent directories that needed to be created,
diff --git a/test/integration/targets/user/tasks/main.yml b/test/integration/targets/user/tasks/main.yml
index 6a3c84eecd7..4af35b28b2a 100644
--- a/test/integration/targets/user/tasks/main.yml
+++ b/test/integration/targets/user/tasks/main.yml
@@ -34,3 +34,6 @@
     - ansible_facts.system == 'Linux'
     - ansible_distribution != 'Alpine'
 - import_tasks: ssh_keygen.yml
+- import_tasks: test_seuser.yml
+  when:
+    - ansible_facts.system in ['FreeBSD', 'OpenBSD', 'Darwin'] or ansible_distribution == 'Alpine'
diff --git a/test/integration/targets/user/tasks/test_seuser.yml b/test/integration/targets/user/tasks/test_seuser.yml
new file mode 100644
index 00000000000..67d34c53596
--- /dev/null
+++ b/test/integration/targets/user/tasks/test_seuser.yml
@@ -0,0 +1,16 @@
+- name: Try creating user with nonexistent SELinux user
+  user:
+    name: badseuser
+    seuser: nonexistent_u
+    state: present
+  register: test_seuser
+
+- name: there should be warnings
+  assert:
+    that: test_seuser.warnings[0] is contains "lacks SELinux support"
+
+- name: Cleanup test account
+  user:
+    name: badseuser
+    state: absent
+    remove: yes
\ No newline at end of file