diff --git a/changelogs/fragments/ec2_vpc_route_table_replace_route_fix.yaml b/changelogs/fragments/ec2_vpc_route_table_replace_route_fix.yaml
new file mode 100644
index 00000000000..143a9e86fb1
--- /dev/null
+++ b/changelogs/fragments/ec2_vpc_route_table_replace_route_fix.yaml
@@ -0,0 +1,4 @@
+---
+bugfixes:
+- ec2_vpc_route_table - check the origin before replacing routes.
+  Routes with the origin 'EnableVgwRoutePropagation' may not be replaced.
diff --git a/lib/ansible/modules/cloud/amazon/ec2_vpc_route_table.py b/lib/ansible/modules/cloud/amazon/ec2_vpc_route_table.py
index 64657eac08c..1567aef29a7 100644
--- a/lib/ansible/modules/cloud/amazon/ec2_vpc_route_table.py
+++ b/lib/ansible/modules/cloud/amazon/ec2_vpc_route_table.py
@@ -432,8 +432,9 @@ def index_of_matching_route(route_spec, routes_to_match):
     for i, route in enumerate(routes_to_match):
         if route_spec_matches_route(route_spec, route):
             return "exact", i
-        elif route_spec_matches_route_cidr(route_spec, route):
-            return "replace", i
+        elif 'Origin' in route_spec and route_spec['Origin'] != 'EnableVgwRoutePropagation':
+            if route_spec_matches_route_cidr(route_spec, route):
+                return "replace", i
 
 
 def ensure_routes(connection=None, module=None, route_table=None, route_specs=None,