diff --git a/changelogs/fragments/65304-fix_zabbix_host_inventory_mode_key_error.yml b/changelogs/fragments/65304-fix_zabbix_host_inventory_mode_key_error.yml
new file mode 100644
index 00000000000..afe6744c76b
--- /dev/null
+++ b/changelogs/fragments/65304-fix_zabbix_host_inventory_mode_key_error.yml
@@ -0,0 +1,2 @@
+bugfixes:
+  - zabbix_host - fixed inventory_mode key error, which occurs with Zabbix 4.4.1 or more (https://github.com/ansible/ansible/issues/65304).
diff --git a/lib/ansible/modules/monitoring/zabbix/zabbix_host.py b/lib/ansible/modules/monitoring/zabbix/zabbix_host.py
index 69f669d10fa..6d9d08d703a 100644
--- a/lib/ansible/modules/monitoring/zabbix/zabbix_host.py
+++ b/lib/ansible/modules/monitoring/zabbix/zabbix_host.py
@@ -287,6 +287,7 @@ except ImportError:
     ZBX_IMP_ERR = traceback.format_exc()
     HAS_ZABBIX_API = False
 
+from distutils.version import LooseVersion
 from ansible.module_utils.basic import AnsibleModule, missing_required_lib
 
 
@@ -294,6 +295,7 @@ class Host(object):
     def __init__(self, module, zbx):
         self._module = module
         self._zapi = zbx
+        self._zbx_api_version = zbx.api_version()[:5]
 
     # exist host
     def is_host_exist(self, host_name):
@@ -542,11 +544,15 @@ class Host(object):
                 return True
 
         if inventory_mode:
-            if host['inventory']:
-                if int(host['inventory']['inventory_mode']) != self.inventory_mode_numeric(inventory_mode):
+            if LooseVersion(self._zbx_api_version) <= LooseVersion('4.4.0'):
+                if host['inventory']:
+                    if int(host['inventory']['inventory_mode']) != self.inventory_mode_numeric(inventory_mode):
+                        return True
+                elif inventory_mode != 'disabled':
+                    return True
+            else:
+                if int(host['inventory_mode']) != self.inventory_mode_numeric(inventory_mode):
                     return True
-            elif inventory_mode != 'disabled':
-                return True
 
         if inventory_zabbix:
             proposed_inventory = copy.deepcopy(host['inventory'])
diff --git a/test/integration/targets/zabbix_host/tasks/zabbix_host_tests.yml b/test/integration/targets/zabbix_host/tasks/zabbix_host_tests.yml
index 1f51677bea3..62f0cb5189c 100644
--- a/test/integration/targets/zabbix_host/tasks/zabbix_host_tests.yml
+++ b/test/integration/targets/zabbix_host/tasks/zabbix_host_tests.yml
@@ -804,6 +804,34 @@
       that:
           - "zabbix_host1 is not changed"
 
+- name: "test: change host inventory mode to disabled"
+  zabbix_host:
+    server_url: "{{ zabbix_server_url }}"
+    login_user: "{{ zabbix_login_user }}"
+    login_password: "{{ zabbix_login_password }}"
+    host_name: ExampleHost
+    inventory_mode: disabled
+  register: zabbix_host1
+
+- name: expect to succeed and that things have changed
+  assert:
+      that:
+          - "zabbix_host1 is changed"
+
+- name: "test: change host inventory mode to manual"
+  zabbix_host:
+    server_url: "{{ zabbix_server_url }}"
+    login_user: "{{ zabbix_login_user }}"
+    login_password: "{{ zabbix_login_password }}"
+    host_name: ExampleHost
+    inventory_mode: manual
+  register: zabbix_host1
+
+- name: expect to succeed and that things have changed
+  assert:
+      that:
+          - "zabbix_host1 is changed"
+
 - name: "test: attempt to delete host created earlier"
   zabbix_host:
     server_url: "{{ zabbix_server_url }}"