diff --git a/changelogs/fragments/42042-inventory_with_no_region.yaml b/changelogs/fragments/42042-inventory_with_no_region.yaml
new file mode 100644
index 00000000000..65ed6458fd6
--- /dev/null
+++ b/changelogs/fragments/42042-inventory_with_no_region.yaml
@@ -0,0 +1,2 @@
+bugfixes:
+- plugins/inventory/openstack.py - Do not create group with empty name if region is not set
diff --git a/lib/ansible/plugins/inventory/openstack.py b/lib/ansible/plugins/inventory/openstack.py
index b2ad6c2ebd3..6105a883951 100644
--- a/lib/ansible/plugins/inventory/openstack.py
+++ b/lib/ansible/plugins/inventory/openstack.py
@@ -258,7 +258,8 @@ class InventoryModule(BaseInventoryPlugin, Constructable, Cacheable):
         groups.append(cloud)
 
         # Create a group on region
-        groups.append(region)
+        if region:
+            groups.append(region)
 
         # And one by cloud_region
         groups.append("%s_%s" % (cloud, region))